Cisplatin resistance in head and neck Horse Leg Straps squamous cell carcinoma (HNSCC) reduces survival.In this study we hypothesized that methylation of key genes mediates cisplatin resistance.We determined whether a demethylating drug, decitabine, could augment the anti-proliferative and apoptotic effects of cisplatin on SCC-25/CP, a cisplatin-re
Large programs of dynamic gene expression, like cell cyles and circadian rhythms, are controlled by a relatively small "core" network of transcription factors and post-translational modifiers, working in concerted mutual regulation.Recent work suggests that system-independent, quantitative features of the dynamics of gene expression can be used to
Revealing the structural features of social networks is vitally important to both scientific research and practice, and the explosive growth of online social networks in recent years has brought us dramatic advances to understand social structures.Here we proposed a community detection approach based on user interaction behavior in weighted dynamic
The article is devoted to the analysis of international cooperation in the field of attracting foreign investment for economic development of Russia.Carrying out investment activities in developing countries and States with economies in transition with their inherent political and economic instability, foreign investor runs the risk that in the eve
ObjectivesWorking-age cancer patients face barriers to resuming work after treatment completion.Those resuming work contend with reduced productivity arising from persisting residual symptoms.Existing studies of return to work (RTW) after cancer diagnosis were done predominantly in Western countries.Given that employment and RTW in cancer DMAE ADVA